Skin Sculpt-Stimulate & Renew Clinical Evidence
Stimulate & Renew
HYDRATING PEPTIDE DAY & NIGHT CREAM
Oenothera Biennis Oil 4%
Olea Europaea Fruit Oil 4%
Triticum Vulgare Germ Oil 4%
Aloe Barbadensis Leaf Juice 3%
Panthenol 1%
Retinol 0.5%
Camellia Sinensis Leaf Extract 0.5%
Ceramide 0.02%
Sodium Hyaluronate 0.01%
Hexapeptide-8 0.001%
Palmitoyl Hexapeptide-12 0.0001%
Oenothera Biennis Oil
Used cosmetically or topically, evening Primrose Oil soothes and moisturises the skin, scalp, and hair while enhancing elasticity. Furthermore, it promotes a healthy, clear, rejuvenated complexion with enhanced radiance and addresses roughness, wrinkles, redness, dryness, and irritation.
Link: https://bit.ly/320M3Ye
Link: https://bit.ly/2UUcL3k
Evening primrose oil has many properties that are beneficial to the health of your skin. Not only does evening primrose oil moisturise and soothe, it can enhance the texture and elasticity of skin, addressing dryness, irritation, roughness and wrinkles. Evening primrose oil is made up of a number of different beneficial constituents, including Omega-6 acids, Omega-9 acids, and Stearic Acid. The key ingredients in evening primrose oil are essential fatty acids that help strengthen the skin barrier and reduce moisture loss. Linoleic Acid which is found in evening primrose oil is an Omega-6 fatty acid that promotes skin health by reinforcing the skin barrier, preserving water in the epidermis and regulating sebum production. If your skin is deficient of essential fatty acids it can lead to dry, rough, or scaly skin.
Link: Data on file.
Oenothera biennis or as it is more commonly known as evening primrose oil is an ingredient used in skincare and cosmetic products to help moisturise the skin and may help to reduce inflammation, irritation and support the treatment of acne. Evening primrose is a flowering plant that is native to North America. It’s loaded with nourishing and moisturising fatty acids. It’s a very rich source of linoleic acid (66-76%), and also contains the soothing and healing superstar fatty acid, gamma-linolenic acid (aka GLA, 7-12%). It also contains oleic acid, at around 6-15%.
Link: https://pubmed.ncbi.nlm.nih.gov/10442214/
Olea Europaea Fruit Oil
Contains natural nutrients and is rich in Oleic Acid. It can be used in a wide variety of personal care formulations for the gentle treatment of the skin, helping to keep it moist and supple.
Link: Data on file.
Triticum Vulgare Germ Oil
This oil enriched seed is a super source of a variety of goodness. It carries a wealth of Omega 3, Vitamin B & E, Folic Acid & Phosphorus, all of which deliver antioxidant & anti-ageing properties.
Link: Data on file
Aloe Barbadensis Leaf Juice
The botanical name of Aloe Vera is Aloe Barbadensis miller. It belongs to Asphodelaceae (Liliaceae) family, and is a shrubby or arborescent, perennial, xerophytic, succulent, pea-green colour plant. It grows mainly in the dry regions of Africa, Asia, Europe and America. Aloe Barbadensis is a useful additive for cosmetics as it has many different properties to counteract the effects of ageing and to protect the skin. Aloe barbadensis, or Aloe Vera, is a succulent plant which offers many benefits and is suited for all skin types, especially dry, damaged, broken, sensitive and irritated skin. It offers anti-inflammatory, antimicrobial, antioxidant, humectant and soothing and anti-itch properties for skin. Aloe Vera contains Vitamin B complex, folic acid, Vitamin C and carotene, which is a precursor of Vitamin A.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763764/
Panthenol
Metabolises in the skin to form Pantothenic Acid.
Is a deep penetration moisturiser.
Stimulates cell proliferation.
Promotes minor wound healing.
Acts as an anti-inflammatory agent.
Is effective in treating acute sunburn.
Link: https://www.ncbi.nlm.nih.gov/pubmed/21982351
Retinol
Retinol is a precursor of retinoic acid and is an effective anti-ageing treatment widely used in cosmetic medicine and is classed as part of the group of topical Vitamin A based drugs called retinoids. Retinoids are widely studied and have been shown to reduce fine lines and wrinkles by increasing the production of collagen. They also stimulate the production of new blood vessels in the skin, which improves skin colour. Additional benefits include fading age spots and softening rough patches of skin. Topical application of retinol significantly affects both cellular and molecular properties of the epidermis and dermis. Tretinoin, was the first retinoid. It was used as an acne treatment in the 1970s, but researchers later discovered that it also fades actinic keratosis spots, evens pigmentation, and speeds the turnover of superficial skin cells.
Vitamin A and its derivatives are among the most effective substances slowing the ageing process. Retinoids regulate the cell apoptosis, differentiation and proliferation. Anti-wrinkle properties of retinoids promote keratinocyte proliferation, strengthen the protective function of the epidermis, restrain trans epidermal water loss, protect collagen against degradation and inhibit metalloproteinases activity.
Link: https://www.ncbi.nlm.nih.gov/pubmed/26578346
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791161/
Camellia Sinensis Leaf Extract - Green Tea Extract
Research has established that topical application of green tea leaves or extracts have many benefits for skin, including anti-ageing properties. The polyphenols in green tea possess potent antioxidant and skin-soothing properties, and show significant promise for improving the appearance of sun-damaged skin. Epigallocatechin gallate (EGCG) is one of the active constituents of green tea believed to be responsible for its many health and appearance benefits, both orally and topically. The primary benefit of green tea is an antioxidant boosting skin against environmental pollutants. Research also shows that the catechins in Green Tea Extract act as a sunblock and as a way to reduce signs of ageing in sun-damaged skin.
Green tea is an anti-inflammatory agent, so it will soothe skin and help prevent redness.
Antioxidant:
Tea Catechins, regarded as the most important antioxidant substance in the human diet, contribute a lot to the beneficial effects to the skin. Oxidative stress is the most important factor in the aging of the skin. Natural oxidants like this are helpful in the prevention of this process. Polyphenols in this extract can have moisturizing and protective effects. Skin roughness is significantly reduced with its use.
Photoprotective Activity:
Ultraviolet radiations ranging from 280-400 nm are very detrimental to the skin. This extract can absorb ultraviolet radiation in harmful range and may also have scavenging properties for radicles produced by UV radiations.
Anti-ageing:
Multiple enzymes including collagenases, hyaluronidase, metalloproteinases, lipoxygenases can have a destructive effect on skin cement lipid. So, Camellia Sinensis by inhibiting these enzymes delays the aging of the skin by preserving hyaluronic acid, elastin, collagen important for the skin. Alkaloids, phenols, and catechins are effective in preventing the formation of cellulite thus further aiding anti-ageing objective.
Anti-Inflammatory:
By inhibiting platelet aggregation, cyclooxygenase (COX-1), and thromboxane synthase (TXAS) production in platelet, it produces anti-inflammatory effect even stronger than commonly used non-steroidal anti-inflammatory drug aspirin. It improves skin microcirculation and protects intracellular cement lipids.
Sebum Production/Acne:
Oily skin, a result of excessive sebum production, accompanied by the problem of acne can be solved by the topical application of its extract. It helps reduce sebum production and have anti-greasy effect too.
Conclusion:
Camellia Sinensis and its extracts can improve skin regeneration by its anti-oxidant, anti-inflammatory, and toning properties. It is strongly soothing, protects against harmful environmental influencers, eliminates excess sebum, and improves skin hydration.
Link: https://www.spandidos-publications.com/ijo/18/6/1307
Link: https://pubmed.ncbi.nlm.nih.gov/23742288/
Link: https://pubmed.ncbi.nlm.nih.gov/23742288/
Link: https://www.ajol.info//index.php/tjpr/article/view/67947
Link: Chu D.H. Overview of Biology, Development, and Structure of Skin. In Fitzpatrick’s Dermatology in General Medicine, 7th ed; Wolff, K., Goldsmith, L.A., Katz, S.I., Gilchrest, B.A., Paller, A.S., Leffell, D.J., Eds.; McGraw-Hill: New York, NY, USA, pp. 57–73
Link: Hodge, Archibald, and Benjamin B. Warfield. Inspiration. Wipf and Stock Publishers, 2008.
Link: https://pubmed.ncbi.nlm.nih.gov/12719785/
Link: https://pubmed.ncbi.nlm.nih.gov/24009859/
Link: https://pubmed.ncbi.nlm.nih.gov/19397954/
Link: https://www.sciencedirect.com/science/article/pii/S0102695X17306725?via%3Dihub
Link: https://pubmed.ncbi.nlm.nih.gov/20846135/
Ceramide NG
Ceramides are lipids that are found naturally in high concentrations in the uppermost layers of skin. They make up over 50% of skin’s composition, they play a vital role in determining skin appearance and how it responds to environmental threats. Ceramides are like the mortar between bricks—if the bricks are your skin cells. Ceramides help hold skin together by forming a protective layer that limits moisture loss and protects against visible damage from pollution and other environmental stressors. In addition, ceramides are one of the anti-ageing ingredients responsible for supporting skin’s dynamic nature.
Ceramides are the major lipid constituent of lamellar sheets present in the intercellular spaces of the stratum corneum. These lamellar sheets are thought to provide the barrier property of the epidermis. It is generally accepted that the intercellular lipid domain is composed of approximately equimolar concentrations of free fatty acids, cholesterol, and ceramides. Ceramides are a structurally heterogeneous and complex group of sphingolipids containing derivatives of sphingosine bases in amide linkage with a variety of fatty acids. Differences in chain length, type and extent of hydroxylation, saturation etc. are responsible for the heterogeneity of the epidermal sphingolipids. It is well known that ceramides play an essential role in structuring and maintaining the water permeability barrier function of the skin.
Link: https://www.ncbi.nlm.nih.gov/pubmed/12553851
Sodium Hyaluronate
Sodium Hyaluronate is the salt form of Hyaluronic Acid, a water-binding ingredient that has the ability to fill the spaces between the connective fibres known as collagen and elastin. Hyaluronic Acid hydrates and separates the skin, allowing it to retain water and create a plumping effect. Sodium Hyaluronate has been used for moisturisation and wound healing since its discover in the 1930s. It is comprised of small molecules that penetrate the skin easily, and can hold up to 1000 their own weight in water. Because the skin naturally loses its water composition as it ages (going from 10% - 20% water to less than 10%), Hyaluronic Acid and Sodium Hyaluronate can replace some of the water lost in the dermis, and potentially fight wrinkles and other signs of ageing. Hyaluronic acid is used in skincare as a humectant and has extreme hydration properties.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583886/
Acetyl Hexapeptide-8
Commonly referred to as “Botox in a jar” because it inhibits the release of neurotransmitters and relaxes the facial muscles, thus reducing expression lines and wrinkles. Acetyl Hexapeptide-8, which is also known as Argireline, is a peptide compound that is used to reduce the appearance of wrinkles brought on by repeated facial expressions. It is composed of chains of amino acids known as peptides. Fine lines and wrinkles around the eyes and mouth usually form because of repeated facial expressions, such as smiling, frowning, or furrowing the brow in deep concentration or frustration. Acetyl hexapeptide 8 can temporarily remove the wrinkles by intercepting messages from the brain, thereby preventing muscle contractions.
Link: https://pubmed.ncbi.nlm.nih.gov/24754410/
Link: https://pubmed.ncbi.nlm.nih.gov/23417317/
Link: https://www.ncbi.nlm.nih.gov/m/pubmed/29371611/?i=1&from=Argireline
Palmitoyl Hexapeptide-12
This peptide is a blend of the fatty acid palmitic acid with several amino acids, including glycine, histidine, and lysine, also known as palmitoyl oligopeptide. A lipopeptide, it helps form layers around and in between skin cells, creating
a barrier that keeps natural moisture intact and prevents it from escaping. Palmitoyl Hexapeptide-12 is a lipopeptide molecule consisting of a lipid connected to Hexapeptide-12. Unlike water soluble peptides, Palmitoyl Hexapeptide-12 is highly biocompatible with skin’s natural structure.
It interacts with cell membranes to boost and revitalize the natural function of the skin cells, renewing them to maximum growth potential. It boosts cell’s natural productivity levels and is considered to be one of the most natural powerful antiageing agents. It acts as a neurotransmitter, stimulates production of collagen and other major extracellular matrix proteins.
A one month double-blind study was conducted on 10 female volunteers, aged 32–56, who performed twice daily applications of a light emulsion containing 4%, or a placebo.